Abstract
Background: To assess whether early health economic modeling helps to distinguish those healthcare innovations that
are potentially cost-effective from those that are not potentially cost-effective. We will also study what information is
retrieved from the health economic models to inform further development, research and implementation decisions.
Methods: We performed secondary analyses on an existing database of 32 health economic modeling assessments of
30 innovations, performed by our group. First, we explored whether the assessments could distinguish innovations
with potential cost-effectiveness from innovations without potential cost-effectiveness. Second, we explored which
recommendations were made regarding development, implementation and further research of the innovation.
Results: Of the 30 innovations, 1 (3%) was an idea that was not yet being developed and 14 (47%) were under development.
Eight (27%) innovations had finished development, and another 7 (23%) innovations were on the market. Although all
assessments showed that the innovation had the potential to become cost-effective, due to improved patient outcomes,
cost savings or both, differences were found in the magnitude of the potential benefits, and the likelihood of reaching
this potential. The assessments informed how the innovation could be further developed or positioned to maximize its
cost-effectiveness, and informed further research.
Conclusion: The early health economic assessments provided insight in the potential cost-effectiveness of an innovation
in its intended context, and the associated uncertainty. None of the assessments resulted in a firm ‘no-go’ recommendation,
but recommendations could be provided on further research and development in order to maximize value for money.