Abstract
Responsible innovation in health (RIH) takes the ideas of responsible research and innovation (RRI) and applies
them to the health sector. This comment takes its point of departure from Lehoux et al which describes a
structured literature review to determine the system-level challenges that health systems in countries at different
levels of human development face. This approach offers interesting insights from the perspective of RRI, but
it also raises the question whether and how RRI can be steered and achieved across healthcare systems. This
includes the question who, if anybody, is responsible for responsible innovation and which insights can be
drawn from the systemic nature RIH.